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Generic Betapace (Sotalol)
Betapace is a beta-blocker used to improve symptoms of arrhythmia, it affects heart and blood circulation.
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Common use

Betapace contains sotalol hydrochloride. It is an antiarrhythmic drug which possesses properties of classes II (beta-adrenoreceptor blocking) and III (cardiac action potential duration prolongation). Betapace is used to treat many forms of supraventricular arrhythmias, and in particular it has advantage over other beta-blockers in treatment of atrial fibrillation (chaotic contractions) fibrillation, atrial flutter (frequent rhythmic constructions). Supraventricular tachycardia (heart rhythm disorder), including Wolff-Parkinson-White syndrome (congenital heart disease characterized by recurrent disorders of heart rhythm and rate) paroxysmal form of atrial fluttering, ventricular tachycardia.



Dosage and direction

The recommended starting dose is 0.04-0.08 g taken 2-3 times daily. If necessary the dose may be increased up to 0.16 g taken 2-3 times daily. Take it orally with a full glass of water before a meal but do not chew the medication.



Precautions

Betapace should be used with cautiousness in the patients with recent myocardial infarction. Limit intake of alcoholic beverages. Discuss with your doctor if you have bronchitis or emphysema, a heart disease or congestive heart failure in history, diabetes, kidney disease, a thyroid disorder, a recent heart attack.



Contraindications

Chronic heart failure, cardiogenic shock, atrioventricular block (disorders of conduction of excitation in conduction system of the heart), arterial hypotension (low blood pressure), sick sinus syndrome, bradycardia, elongated QT interval on the electrocardiogram, hypokalemia (decreased potassium levels in the blood), obliterative artery diseases, obstructive pulmonary disease, metabolic acidosis, hypersensitivity to the components of the drug. Caution must be exercised in the appointment of sotalol patients with recent myocardial infarction.



Possible side effect

Side effects of Betapace are associated with its property to block beta-adrenoreceptors. Sinus bradycardia (rare heart rate) was reported in 9-11% of patients together with symptoms of heart failure. You may experience these such effects: lightheadedness, headache, drowsiness, dizziness, stomach upset, or blurred vision, cough, trouble sleeping, reduced concentration, dry skin, decreased sexual desire, altered taste, or muscle aches. Notify your doctor if the adverse reactions listed above and also if the following adverse reactions aggravate: mental confusion, trouble urinating, easy bruising or bleeding, chest pain, skin rash, sore throat, breathing trouble, fainting, irregular heartbeat.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medicines and herbal products you are taking and especially about: medication for blood pressure (clonidine), antacids, St John's wort, anti-diabetic drugs, calcium channel blockers (verapamil, diltiazem), arbutamine, aspirin/NSAIDS (ibuprofen, naproxen), drugs which may change heart rhythm such as "water pills" (diuretics such as furosemide or hydrochlorothiazide), quinidine, procainamide, sparfloxacin, dofetilide, pimozide. Follow all directions of your doctor and avoid taking medication for allergies or cough or colds without his permission.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Symptoms of overdose may include chest pain, swelling, hunger, slow or fast heartbeats, shortness of breath, weakness, confusion, seizure, sweating, feeling light-headed, fainting.



Storage

Betapace should be stored at room temperature between 15-30 C (59-86 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Vardenafil work and what pharmaceutical group does it belong to?

Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.

Which conditions are treated with Vardenafil ?

Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.

What should a patient know prior to taking the medication?

  • Vardenafil should not be taken in known hypersensitivity or allergy to any of the medication ingredients.
  • Vardenafil is not intended to treat children and adolescents under 18 years of age.
  • Vardenafil should be used with caution in prolonged QT interval, anatomical deformation of the penis, priapism, blood diseases, severe liver and kidney diseases, arterial hypotension, recent heart attacks and strokes, tendency to bleedings, aggravation of stomach ulcers, aortal stenosis, idiopathic hypertrophic
  • Vardenafil is indicated only for men and should not be used by women.

Which adverse effects may manifest when using the medication?

The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.

In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Vardenafil?

The drug is affected by the following:

  • Alpha blockers
  • Heart arrhythmia medicines
  • Certain antibiotics
  • Grapefruit juice
  • Nitrates
  • Protease inhibitors

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.