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Brand Levitra causes widening and relaxation of the blood vessels carrying blood to the penis.
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Common use
Brand Levitra was developed by the pharmaceutical company Bayer/GlaxoSmithKline and uses Vardenafil HCl as main component of the medication. Levitra is an oral drug used to treat erectile dysfunction. Sexual stimulation causes the production and release of nitric oxide from the nerves endings of the cavernous bodies of the penis hereby activating enzyme guanylate cyclase. Guanylate cyclase in its turn is responsible for production of cyclic guanosine monophosphate (cGMP). The cGMP causes widening and relaxation of the blood vessels carrying blood to the penis. Levitra prevents phosphodiesterase-5 enzyme from destroying cGMP and thus helps to support blood flow to the penis.
Dosage and direction
The recommended dose of Levitra is 10 mg per day taken an hour before intercourse. If no side effects are experienced the dosage can be increased up to 20 mg. In case of adverse effects the dose is reduced to 5 mg daily. Do not take more than one tab of Levitra a day.
Precautions
Levitra has not been studied in people with cardiovascular disease, so it is preferable to avoid Levitra if in patients who have a stroke or heart failure, or a heart attack in history and especially within last six month. Before to take Levitra inform your doctor if you have kidney or liver problems, a bleeding disorder, stomach ulcer, or an inherited retinal disorder such as retinitis pigmentosa, allergic reaction to this medicine or any other medicines, deformation of the penis such as angulation, cavernous fibrosis (Peyronie's disease), as well as in diseases that contribute to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, or leukemia).
Contraindications
Levitra is contraindicated in patients with hypersensitivity to its ingredients, ones treated with organic nitrates, in patients under 16 y.o., or those who take HIV protease inhibitors such as indinavir and ritonavir.
Possible side effect
Levitra is usually well tolerated and side effects if occur are transient. The most frequent side effects are: headache, flushing (hyperemia of the person); frequent; dizziness, diarrhea phenomenon, nausea, nasal congestion. More rare and uncommon adverse effects are photosensitivity of skin, hypertension, back pain, watery eyes, hypotension, myalgia, priapism.
Drug interaction
Levitra's metabolism is inhibited by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Levitra reduces the concentration of ritonavir and indinavir. In patients treated with nitrates Levitra may aggravate chest pain by increasing heart rate and lowering blood pressure. Levitra is able to exaggerate the blood pressure lowering effects of alpha-blocking drugs (terazosin or Hytrin). Levitra never should be administered in patients who are treated with organic nitrates.
Missed dose
Levitra is taken when needed but not more often than once daily so missed dose is not supposed.
Overdose
Symptoms of overdose include pain in the back, jaw, arm, blindness, blurred vision, chest pain or discomfort, decreased vision, blurred vision.
Storage
Store at room temperature between 15-30 C (59-86 F) away from children, pets, moisture and sunlight.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.
Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.
The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.
In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.
It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.
The drug is affected by the following:
Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.
Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.