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Levitra24hrs
Generic Clonidine (Clonidine )
Clonidine is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs.
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Common use

Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. It acts changing concentration of certain chemicals in blood and stimulating alpha2-adrenoceptors in the brain stem that reduces transmission of a signal from brain to other areas in the body. Its action results in a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.



Dosage and direction

Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. Do not use this drug if it was not prescribed to you by your physician. In case you use patches they should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When you change the patch for a new one, choose a different area of skin.



Precautions

Avoid drinking alcohol, be especially attentive if you need to drive or make any work which requires high concentration of attention.



Contraindications

Hypersensitivity to Clonidine or any component of the formulation. Contraindication may also include in patients with sick sinus syndrome, bradicardia, atrioventricular block (degree II and III). Cautiousness should be exercised in cases of acute myocardial infraction, Reino syndrome, endogenous depression kidney failure and others.



Possible side effect

Beside of signs of allergic reaction such as hives, difficulty breathing, swelling such side effects may appear: fast or pounding heartbeats, a very slow heart rate, swelling, rapid weight gain, confusion, hallucinations, fever, pale skin, urinating less than usual. If you experience them seek for immediate medical attention.



Drug interaction

Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. Certain antidepressants may diminish pharmaceutical effect of Clonidine. Kidney damage maybe caused by increased concentration of Cyclosporine when Clonidine is administered concurrently. Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness.



Missed dose

If you missed a dose take it as soon as you remember, but if it is almost time of your next dose, just skip the forgotten dose. Do not try to compensate a missed dose by taking an extra one.



Overdose

If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention.



Storage

Tablets and patches should be stored at room temperature 15-30 C (59-86 F) in a light- resistant container away from moisture.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Vardenafil work and what pharmaceutical group does it belong to?

Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.

Which conditions are treated with Vardenafil ?

Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.

What should a patient know prior to taking the medication?

  • Vardenafil should not be taken in known hypersensitivity or allergy to any of the medication ingredients.
  • Vardenafil is not intended to treat children and adolescents under 18 years of age.
  • Vardenafil should be used with caution in prolonged QT interval, anatomical deformation of the penis, priapism, blood diseases, severe liver and kidney diseases, arterial hypotension, recent heart attacks and strokes, tendency to bleedings, aggravation of stomach ulcers, aortal stenosis, idiopathic hypertrophic
  • Vardenafil is indicated only for men and should not be used by women.

Which adverse effects may manifest when using the medication?

The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.

In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Vardenafil?

The drug is affected by the following:

  • Alpha blockers
  • Heart arrhythmia medicines
  • Certain antibiotics
  • Grapefruit juice
  • Nitrates
  • Protease inhibitors

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.