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Generic Flibanserin (Flibanserin)
Flibanserin is sold under the trade name Addyi and used to treat decreased sexual desire in women who have not gone through menopause and who have never had low sexual desire in the past. Flibanserin is for use only when low sexual desire is not caused by a medical condition, a mental disorder, relationship problems, or by using drugs or other medicines.
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Common use

The main component of Fliban is flibanserin - 100 mg.

Flibanserin preferentially activates 5-HT1A receptors in the prefrontal cortex demonstrating regional selectivity, and has been found to increase dopamine and norepinephrine levels and decrease serotonin levels in the rat prefrontal cortex, actions that were determined to be mediated by activation of the 5-HT1A receptor.



Dosage and direction

Fliban is taken 100 mg orally once per day at bedtime in cases of hypoactive sexual desire disorder (HSDD) treatment.

The onset of the flibanserin effect was seen from the first time point measured after 4 weeks of treatment and maintained throughout the treatment period. You should stop taking Fliban after 4 weeks if there is no improvement in symptoms.

This drug is not indicated to enhance sexual performance, and is not indicated for treatment in postmenopausal women or in men.

Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance.



Precautions

It is strongly recommended to consult your doctor or pharmacist before you start taking flibanserin and especially emphasize if you are allergic to this drug or if you have any other allergies.

You must not drink alcohol while taking Fliban. It may cause you to have dangerously low blood pressure.

Also you should not use Fliban if you have: low blood pressure, a history of alcoholism or drug addiction, liver disease, a history of depression or mental illness, or if you currently drink alcohol.

Some medicines can cause unwanted or dangerous effects when used with Fliban. Your doctor may need to change your treatment plan if you use any of the following drugs: nefazodone, ciprofloxacin, larithromycin, erythromycin, telithromycin, fluconazole, itraconazole, ketoconazole, posaconazole, boceprevir, telaprevir, conivaptan, diltiazem, verapamil, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

Flibanserin may impair your thinking or reactions. Avoid driving or operating machinery for at least 6 hours after you take this medicine, and until you know how this medicine will affect you. Dizziness or low blood pressure can cause falls or other accidents.

It is not known whether flibanserin will harm an unborn baby. Consult your doctor or pharmacist if you are pregnant or planning to become pregnant.

It is not known whether flibanserin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.



Contraindications

Do not drink alcohol while taking Fliban. Drinking alcohol with this medicine can cause dangerous or unwanted side effects.

Grapefruit and grapefruit juice may interact with flibanserin and lead to unwanted side effects. Avoid the use of grapefruit products while taking Fliban.

Avoid taking herbal supplement containing: ginkgo biloba, resveratrol, St. John's wort.

Fliban is contra-indicated if patients taking another medicine to treat hypoactive sexual desire disorder or using drugs against high blood pressure.

Fliban is not approved for use by men and children younger than 18 years old.



Possible side effect

Get emergency medical help if you have signs of an allergic reaction to Fliban: hives, difficult breathing, your face, lips, tongue, or throat swelling.

Call your doctor at once if you feeling very drowsy or light-headed like you might pass out.

Common Fliban side effects may include: dizziness, nausea, fatigue, nausea, dry mouth, sleepiness or trouble sleeping.

In case you notice any of these side effects or other not listed above - contact your doctor or pharmacist.



Drug interaction

Taking this medicine with other drugs that make you sleepy or lower your blood pressure can worsen Fliban effect. Consult your doctor before taking Fliban with sleeping pills, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially: cimetidine, ginkgo biloba, resveratrol, St. John's wort.

Your doctor also may need to change your treatment plan if you use any of the following antibiotic, antifungal, antiviral, heart or blood pressure, HIV or AIDS drugs: nefazodone, ciprofloxacin, larithromycin, erythromycin, telithromycin, fluconazole, itraconazole, ketoconazole, posaconazole, boceprevir, telaprevir, conivaptan, diltiazem, verapamil, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

This list is not complete. Other drugs may interact with flibanserin including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Contact your doctor or pharmacist for more details.



Missed dose

If so happened that you missed a dose - skip it and take the medicine the following day at bedtime. Do not take Fliban in the morning and do not take extra medicine to make up the missed dose.



Overdose

If you think you have used too much of Fliban - seek emergency medical attention or call the Poison Help line at 1-800-222-1222.



Storage

Store Fliban within the room temperature not higher than 77° F (20-25° C). Store away from moisture and heat. Do not store drugs in the bathroom. Keep all drugs out of the reach children and animals.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Vardenafil work and what pharmaceutical group does it belong to?

Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.

Which conditions are treated with Vardenafil ?

Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.

What should a patient know prior to taking the medication?

  • Vardenafil should not be taken in known hypersensitivity or allergy to any of the medication ingredients.
  • Vardenafil is not intended to treat children and adolescents under 18 years of age.
  • Vardenafil should be used with caution in prolonged QT interval, anatomical deformation of the penis, priapism, blood diseases, severe liver and kidney diseases, arterial hypotension, recent heart attacks and strokes, tendency to bleedings, aggravation of stomach ulcers, aortal stenosis, idiopathic hypertrophic
  • Vardenafil is indicated only for men and should not be used by women.

Which adverse effects may manifest when using the medication?

The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.

In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Vardenafil?

The drug is affected by the following:

  • Alpha blockers
  • Heart arrhythmia medicines
  • Certain antibiotics
  • Grapefruit juice
  • Nitrates
  • Protease inhibitors

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.