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Generic Nizoral (Ketoconazole)
Nizoral is an antifungal antibiotic which is used to treat candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis.
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Common use

Nizoral is an antifungal antibiotic which is used to treat serious fungal or yeast infections, such as candidiasis, blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis, or paracoccidioidomycosis. Nizoral kills sensitive fungi by interfering with the formation of the fungal cell membrane. Also Nizoral is used to treat parasitic fungal infections on the skin that cannot be treated with topical medicine or griseofulvin, or for patients who cannot take griseofulvin.



Dosage and direction

Take it orally with food or milk at the same time each day.

The recommended starting dose for adults is 200 mg once a day.

Dosage for children 2 year old is based on body weight and consist a single daily dose of 3.3 to 6.6 mg/kg . Do not use it without doctor's permission and dose has to be prescribed just after consulting with your doctor.

For children up to 2 years of age use it just after doctor's permission and dose has to be prescribed after consulting with your doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.



Precautions

Liver problems may occur while you are taking this medicine. If you experience one of this symptoms: dark urine; abdominal pain or tenderness; clay-colored stools; nausea and vomiting; decreased appetite; skin rash; fever; headache; itching; loss of appetite; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin call your doctor immediately . Nizoral should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use this drug before breast-feeding without doctor's permission.



Contraindications

Nizoral is not allowed to people who are hypersensitive to any components of this medication. Also it is contraindicated with terfenadine, astemizole, triazolam, cisapride.



Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include:

dizziness, fainting, fast or pounding heartbeat;

easy bruising or bleeding, unusual weakness;

numbness or tingly feeling;

severe depression, confusion, or thoughts of hurting yourself; or

nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious include:

mild nausea, vomiting, or stomach pain;

mild itching or skin rash;

headache;

dizziness;

breast swelling; or

impotence or loss of interest in sex.

If you experience one of them stop using Nizoral and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.



Drug interaction

Nizoral interact with follow list of drugs: acetaminophen (Tylenol); cyclosporine (Gengraf, Sandimmune, Neoral); digoxin (digitalis, Lanoxin); tacrolimus ((Prograf); loratadine (Alavert, Claritin, Tavist ND); methylprednisolone (Medrol); phenytoin (Dilantin); rifampin (Rifadin, Rifater, Rifamate, Rimactane); diabetes medication you take by mouth; a sedative such as midazolam (Versed); a blood thinner such as warfarin (Coumadin); cancer medications; birth control pills or hormone replacement therapy; methotrexate (Rheumatrex, Trexall); cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or medications to treat HIV or AIDS. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.



Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.



Overdose

Symptoms of Nizoral overdose are not known well, but if you experience any unusual symptoms call your doctor immediately. Also in the event of accidental over-dosage, supportive measures, including gastric lavage with sodium bicarbonate, should be employed.



Storage

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Vardenafil work and what pharmaceutical group does it belong to?

Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.

Which conditions are treated with Vardenafil ?

Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.

What should a patient know prior to taking the medication?

  • Vardenafil should not be taken in known hypersensitivity or allergy to any of the medication ingredients.
  • Vardenafil is not intended to treat children and adolescents under 18 years of age.
  • Vardenafil should be used with caution in prolonged QT interval, anatomical deformation of the penis, priapism, blood diseases, severe liver and kidney diseases, arterial hypotension, recent heart attacks and strokes, tendency to bleedings, aggravation of stomach ulcers, aortal stenosis, idiopathic hypertrophic
  • Vardenafil is indicated only for men and should not be used by women.

Which adverse effects may manifest when using the medication?

The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.

In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Vardenafil?

The drug is affected by the following:

  • Alpha blockers
  • Heart arrhythmia medicines
  • Certain antibiotics
  • Grapefruit juice
  • Nitrates
  • Protease inhibitors

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.