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Generic Zyvox (Linezolid)
Zyvox is an oxazolidinones antibiotic to treat infections caused by Enterococcus and Streptococcus.
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Common use

Zyvox is a synthetic oxazolidinones antibiotic and contains a linezolid. It is used against infections caused by Enterococcus faecium, Staphylococcus aureus, Streptococcus pneumoniae (pneumonia), Streptococcus pyogenes, Streptococcus agalactiae (skin infections, including diabetic foot infections), Streptococcus pyogenes (skin infections).



Dosage and direction

Take it orally every twelve hours or as directed by your doctor. Intake at evenly spaced intervals is recommended. Take with or without food. Do not stop treatment with Zyvox even if your symptoms improve after a few days, or you may cause propagation of resistant strains. Inform your doctor if your symptoms do not become better in 10 days.



Precautions

Lactic acidosis may develop while taking Zyvox for the period longer than 28 days. Inform your doctor if you experience such symptoms as light-headedness, dizziness, extreme weakness or tiredness, low body temperature, rapid breathing, difficulty breathing, sleepiness, slow or irregular heartbeat, stomach discomfort, muscle pain. Treatment which continues over 28 days may cause blurred vision, change in color perception. Contact your doctor immediately if you find changes in your vision. Liquid formulation of Zyvox contains phenylalanine and can be dangerous for patients with phenylketonuria.

If you take treatment with antidepressants called selective serotonin reuptake inhibitors (SSRIs), a serotonin syndrome may develop. Its symptoms are: drowsiness, euphoria, rapid muscle contraction and relaxation,dizziness, restlessness, coordination problems, sweating, and fever. Avoid eating too much food with high tyramine content: aged cheese, fermented or air-dried meats (dry sausage, sauerkraut), red wine, tap beers, soy sauce, and any improperly refrigerated protein-rich food. Inform your doctor if you are pregnant or breastfeeding, have hypertension, blood disorders (low blood counts), any allergies, chronic infection.



Contraindications

Hypersensitivity to oxazolidinones antibiotics.



Possible side effect

Diarrhea, headache, nausea, vomiting, trouble sleeping, or rash. In case of unusual side effects like easy bruising or bleeding, severe dizziness, severe headache, vision changes, tingling and numbness of extremities, fever contact your doctor immediately.



Drug interaction

Inform your doctor if you are taking: apraclonidine, brimonidine, buspirone, bethanidine, bupropion, carbamazepine, entacapone, dextromethorphan, herbal products (ma huang), indoramin, papaverine, meperidine, sibutramine, SSRI antidepressants (fluoxetine, citalopram), tolcapone, sympathomimetics (methylphenidate, ephedrine), tricyclic antidepressants (amitriptyline, doxepin), "triptans" ( sumatriptan, zolmitriptan), other antibiotics, other drugs for cancer chemotherapy or others which can depress the bone marrow, other MAO inhibitors (furazolidone, moclobemide, phenelzine, procarbazine), cough-and-cold products, diet aids.



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Any medication taken in excessive quantities may be dangerous. Notify your doctor immediately in case of a supposed overdose.



Storage

Zyvox should be stored at room temperature between 20-25 C (68-77 F).



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

How does Vardenafil work and what pharmaceutical group does it belong to?

Erection of the penis is a haemodynamic process that is based on the relaxation of the cavernous body's smooth muscles and its arterioles. During sexual stimulation nitrogen oxide is released from the cavernous body's nerve ends and activates the enzyme cGMP. This results in relaxation of the smooth muscles in the cavernous body and increases blood flow to the penis. Vardenafil works by blocking PDE type 5(phosphodiesterase type 5) that is responsible for the inactivation of cGMP. This in its turn increases the amount of cGMP and improves erection.

Which conditions are treated with Vardenafil ?

Vardenafil is indicated for the treatment of erectile dysfunction manifested in inability to achieve and maintain erection, enough for the sexual intercourse.

What should a patient know prior to taking the medication?

  • Vardenafil should not be taken in known hypersensitivity or allergy to any of the medication ingredients.
  • Vardenafil is not intended to treat children and adolescents under 18 years of age.
  • Vardenafil should be used with caution in prolonged QT interval, anatomical deformation of the penis, priapism, blood diseases, severe liver and kidney diseases, arterial hypotension, recent heart attacks and strokes, tendency to bleedings, aggravation of stomach ulcers, aortal stenosis, idiopathic hypertrophic
  • Vardenafil is indicated only for men and should not be used by women.

Which adverse effects may manifest when using the medication?

The side effects of Vardenafil include: headache, hot flushing, dyspepsia, upset stomach, rhinitis, flu-like symptoms, increased levels of creatine kinase in the blood, nausea, dizziness, back pain.

In rare cases Vardenafil may cause arthritis, diarrhea, insomnia, muscle pain, blurred vision and others.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Vardenafil?

The drug is affected by the following:

  • Alpha blockers
  • Heart arrhythmia medicines
  • Certain antibiotics
  • Grapefruit juice
  • Nitrates
  • Protease inhibitors

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Vardenafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.